Another datapoint, not saying much that has not been said. I bought a, umm, 95 or 96 (forget) E350 (351 v8) 12 passenger van several years ago. It had ~88k on it when I bought it, has 142k on it now. I removed all but the forward-most rear seat, built a "bed" back there, on the driver's side, enough room to slide a motorcycle in on the p-side. It holds a TON of stuff. Problems I've had:
3 sets of front pads. It really needs rotors, as someone ran them metal-to-metal at one point, but whatever.
Ball joints, tie rod ends and transmission at ~108k (THAT'S why I got it cheap.....)
Fuel pump (possibly due to the sugar some d-nozzle put in my tank...not the van's fault)
Rear driveshaft got wobbly this winter
Connections at the relay for the cabin fan corrode annually, for some reason.
Mine is ugly; d-side fender and hood are a mess. I replaced the spark plugs at ~100k miles, they needed it, and it is not a fun job. Mine is a total basemodel - rolly-rolly windows, lousy seats, although it does have a rear heater AND FM. Luxury.
It gets ~12mpg towing the car (light trailer, 2000# car). 16ish combined unloaded. Somewhere in between dragging motorcycles and snowmobiles.
It is very good in snow, with snow tires. I've had to chain it up ~3 times, unload the sleds to get it back up the parking lot road a few times. I do use studded snows, but despite the open diff and frequently nasty forest service parking lots/plowing, it gets around great. I kinda want to put an airlocker in it.
It is the default ski/bike/car vehicle - room to change, sleep, carry all kinds of stuff, whatever. Drove to Lincoln and back last weekend, averaged about 70mph both ways (including stops). Mileage drops significantly over about 75mph.
Beyond normal maintenance, I did replace the stock muffler with 3" pipe from the cat back, through a big Magnaflow. A SMIDGE louder (very, very tolerable, the juvenile in me wishes it was louder), but instantly gained 1.5ish mpg.
I really like mine. Sometimes, I wish I'd ponied up for a 4wd one, but I suspect I'd lose the comfort, or a portion of it; that said, when it is 5F outside and unloading sleds before being dressed appropriately so we can get back up to the parking spot and not block the turnaround, I do long for The Button. That does not happen often, and when it does, the skiing is _going_ to be good, so I get over it.
I kinda wish I had a 15 passenger, but the overhang seems to cause some problems for some people, and if I pack more efficiently (as opposed to hucking crap in), I'll never run out of room.
I've put 3 motorcycles/people/stuff inside it for a weekend of dirtbiking in Utah. I've driven it on "4x4 recommended" roads/trails in Moab. It has never failed to get me to wherever I want to go in the snow (and the more it snows, the more I want to go).
Power - I think the 351 is rated at 240/300. Flat ground, fine. Towing over the higher passes in CO, it works pretty hard. More power would be nice, and I'd not want to hitch a big enclosed trailer to it from a power standpoint, but for an open trailer, it is fine. I think I averaged ~45mph going up to the Eisenhower/Johnson tunnels (~8 miles of relatively steep highway at 9-11k feet). Not bad. Still passing people. Not complaining. More would be better, but for typical use - Denver to Wendover, Lincoln, Topeka, etc - the 351 is fine. A V10 would likely be better, or diesel, but I'm very satisfied with it's power; cruising at a reasonable speed relative to other traffic does not seem abusive.
Dunno. Easily my favorite non-fun car I've owned.